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Custom Synthesis of Deuterated Chemicals
At ResolveMass Laboratories Inc., we specialize in the custom synthesis of deuterated chemicals that empower scientists, pharmaceutical developers, and material researchers to achieve precise and reliable results. With deepf experience in stable isotope chemistry, our team delivers tailor-made deuterated molecules optimized for analytical, pharmacokinetic, and advanced material applications. Each project is handled with scientific rigor and a commitment to accuracy.
Why Researchers Trust ResolveMass for Custom Deuterated Compound Synthesis
ResolveMass Laboratories leads in the field of isotopic labeling and deuterium chemistry. We provide scalable, high-purity deuterated compounds for pharmaceutical, materials, and analytical research applications. Our chemists possess extensive experience in synthesizing small molecules, polymers, and complex isotopic derivatives, ensuring reliable results every time.
- Precision-controlled isotope incorporation and reproducibility
- In-house analytical validation using NMR, LC-MS, and IR spectroscopy
- Scalable synthesis from milligram to kilogram levels
- Confidential, IP-secure, and traceable workflows
- Proven capabilities in complex molecular architectures
Explore how to choose the right custom synthesis provider or learn when custom synthesis is most needed
Experience That Drives Innovation in Deuterium Chemistry
From deuterated small molecules to complex polymers, our synthesis capabilities support every stage of your research — from early discovery through to full-scale development. Every project is guided by Ph.D.-level chemists who specialize in isotopic substitution techniques, ensuring optimal isotopic enrichment, superior chemical purity, and complete analytical traceability.
Read about our work in custom polymer synthesis and detailed case studies in small molecule synthesis.
Applications Across Scientific Disciplines
Deuterated compounds play a vital role across pharmaceutical, analytical, and materials sciences. Through our custom synthesis services, researchers gain access to precision-labeled molecules that enhance study accuracy and performance in various disciplines.
- Pharmaceutical R&D: ADME profiling, metabolic pathway tracing, and stability improvement
- Analytical Chemistry: Enhanced NMR resolution and minimized spectral overlap
- Material Science: Improved chemical stability for polymers and coatings
- AI-Driven Research: Automated optimization and design of isotope-labeled compounds (Learn more)
Discover our insights on deuterated polymers and their future applications and deuterated acrylamide derivatives for advanced NMR research.
Our Proven Process for Deuterated Chemical Synthesis
Consultation & Feasibility Study – We begin by understanding your molecular target, objectives, and analytical needs.
Synthetic Route Design – Our team identifies isotopic exchange sites and evaluates molecular stability.
Pilot-Scale Production – The process is optimized for yield, isotopic incorporation, and purity.
Analytical Verification – Advanced techniques such as LC-MS, IR, and NMR confirm purity and enrichment levels.
Delivery & Continued Support – Comprehensive analytical documentation accompanies every batch, with ongoing technical guidance available.
Quality You Can Trust
Every ResolveMass project adheres to strict internal quality systems and GLP-aligned practices. Our facilities operate with full traceability and confidentiality, supported by client-exclusive NDAs. We safeguard intellectual property and ensure every synthesized compound meets the highest scientific and regulatory standards.
Explore More from ResolveMass
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Partner with ResolveMass for Custom Synthesis of Deuterated Chemicals
Looking to start your next project? Our expert chemists will design a synthesis strategy tailored to your research requirements and delivery timelines. Contact us today to discuss your objectives and receive a personalized synthesis plan.
Frequently Asked Questions
Custom synthesis of deuterated compounds involves substituting hydrogen atoms with deuterium (²H), a stable isotope of hydrogen. This process enhances molecular stability, boosts NMR performance, and supports precise metabolic or analytical studies. ResolveMass Laboratories delivers tailor-made deuterated molecules that ensure purity, reproducibility, and research reliability.
Deuterated compounds improve the pharmacokinetic properties of drugs by enhancing metabolic stability and reducing degradation rates. They are indispensable in ADME studies, pharmacokinetic modeling, and the development of safer, longer-lasting drug candidates. Their role in drug discovery and optimization continues to expand in modern pharmaceutical innovation.
Our laboratory utilizes advanced analytical instruments, including LC-MS, ¹H/²H NMR, and IR spectroscopy, to verify isotopic enrichment and chemical purity. Each synthesis batch undergoes stringent, multi-stage validation, ensuring accuracy, reproducibility, and compliance with the highest laboratory standards.
Yes. Every compound delivered includes comprehensive analytical data such as NMR, LC-MS, IR spectra, and elemental analysis. These reports confirm isotopic incorporation, molecular identity, and overall sample purity.
We manage projects from small-scale research synthesis (milligram quantities) to pilot and industrial-scale production (multi-gram and kilogram levels). This scalability allows researchers to transition smoothly from discovery to full-scale testing or commercialization.
References
- Kopf, S., Bourriquen, F., Li, W., … & Morandi, B. (2022). Recent developments for the deuterium and tritium labeling of organic molecules. Chemical Reviews, 122(6), 6634-6713. https://doi.org/10.1021/acs.chemrev.1c00795
- Di Martino, R. M., Maxwell, B. D., & Pirali, T. (2023). Deuterium in drug discovery: Progress, opportunities and challenges. Nature Reviews Drug Discovery, 22(7), 562–584. https://doi.org/10.1038/s41573-023-00703-8
- Munir, R., Zahoor, A. F., Khan, S. G., Hussain, S. M., Noreen, R., Mansha, A., Hafeez, F., Irfan, A., & Ahmad, M. (2025, August 21). Total syntheses of deuterated drugs: A comprehensive review. Top Current Chemistry (Cham), 383(3), 31. https://doi.org/10.1007/s41061-025-00515-x